Sulfated polysaccharides from brown seaweeds exhibit various biological activities,structural diversity, and are potential reagents for the development of therapeutic drugs. This study aimed to determine the effect of aqueous (AQ) and fucoidan (F1) extracts fromSargassumsiliquosumJ. G Agardhon viability of peripheral blood mononuclear cells, production of pro-inflammatory cytokines and plasma coagulation using in vitro assays. Sulfate contents of the polysaccharides were quantitated using Acid-Ashing Digestion Ion chromatography. Effects on viability of the extracts on peripheral blood mononuclear cells (PBMC) wasdetermined by MTT Assay. Estimation of pro-inflammatory cytokines concentrations was done through Enzyme-Linked Immunosorbent Assay (ELISA), while anticoagulant activity was measured by Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT). Results revealed that both extracts were non-cytotoxic to PBMCs, reduced significantly the production of IL-1, IL-6, TNF-α and exhibited normal anticoagulant activity in PT assays and prolonged APTT remarkably in dose-dependent manner. In conclusion, extracts of the Sargassumsiliquosum J.G. Agardh is a potential alternative source in producing anti-inflammatory and anticoagulant substances in the future.

This study is for the effects of some Indian medicinal plants that are claimed to be useful in the treatment of obesity are reviewed. Research studies are being carried out to detect and confirm the action of drugs and natural products that yield better and long-lasting results in terms of weight reduction. In this field, medicinal plants play a pivotal role. The statins inhibit 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase and, thereby, suppress cholesterol biosynthesis.

This study is for the effects of some Indian medicinal plants that are claimed to be useful in the treatment of obesity are reviewed. Research studies are being carried out to detect and confirm the action of drugs and natural products that yield better and long-lasting results in terms of weight reduction. In this field, medicinal plants play a pivotal role. The statins inhibit 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase and, thereby, suppress cholesterol biosynthesis.

The present study was aimed to explore the phytochemical constituents present in various extarcts of Ulva lactuca Linn and produce the FT-IR, TLC, UV-VIS and HPLC spectrum profile for U. lactuca. Phytochemical screening of the extracts was carried out according to the method described by Harborne. For the HPLC analysis, the methanol: water (45:55) was used as mobile phase. The results of phytochemical analysis revealed the presence of steroids, phenolic groups, alkaloids, saponins, tannins, glycosides and terpenoids in U. lactuca. The UV- VIS profile of aqueous, ethanolic, chloroform, petroleum ether and hexane confirmed various metabolites and functional groups presence in the crude extracts of U. lactuca. The HPLC profile of U. lactuca ethanolic extract showed some prominent and moderate peaks with different retention time. The results of the present study showed that U. lactuca may be rich sources of phytoconstituents which can be isolated and further to exploit for developing plant based drugs for various ailments.

A new series of Thiazolidine-4-one showed diversified antibacterial activities. In view of potential antibacterial activities of thiazolidine-4- one derivative were prepared by schiffs base technique. The compound were screened by antibacterial activity, thiazolidine -4-one also showed antifungal acyivity, hypoglycemic activity, anti-convulsant activity, analgesic activity, anti-tubercular activity and anti-inflammatory activity.Thiazolidine-4-one also related to ketone group, amine group,sulpher group and thiazolidine ring.

Literature survey reveals that, amoebiasis is the second leading cause of death from parasitic disease worldwide. The causative protozoan parasite, Entamoeba histolytica, is a potent pathogen. Oral delivery of drugs in the colon is valuable in the treatment of diseases of colon like amoebiasis whereby high local concentration can be achieved while minimizing side effects. Satranidazole was selected as the drug of choice because it is most potent nitroimidazole derivative and clinically useful against common protozoa; it is twice as effective as other nitroimidazole against amoebiasis. Colon targeted tablet of satranidazole can maintain minimum inhibitory concentration (MIC90) for desired duration in fewer doses and even with fewer side effects. The colon targeted matrix tablet of satranidazole which is composed of polysaccharides which are susceptible to enzymatic egradation i.e. Guar gum, Xanthan gum, Guar: Xanthan gum in combination at 2 ratios (1:1) and (2:1) and Pectin coated with enteric polymer Eudragit L, Eudragit S and Eudragit RS in ratio of 4:16:5 with less quantity of plasticizer PEG 400 showed excellent film properties and were able to release most of the drug into colon. 10% of coating was found to be optimum. Analytical methods were developed for the drug, and calibration curves were prepared in SGF, SIF, and SCF. Formulation SF7 was considered as optimum batch as it delivered 96 % of drug into colon. The in vivo studies showed that tablet does not disintegrate in stomach and small intestine and site of disintegration was found to be descending colon. The formulation SF7 can be employed as a promising colon specific drug delivery system of satranidazole.

Here sulfonamide analogues have been used to correlate the inhibition constant with the McGowan volume and ALogP descriptors for studying the Quantitative Structure Activity Relationship (QSAR). Correlation may be an adequate predictive model which can help to provide guidance in designing and subsequently yielding greatly specific compounds that may have reduced side effects and improved pharmacological activities. We have used Multiple Linear Regression (MLR) for developing QSAR model. For the validation of the developed QSAR model, statistical analysis such as cross validation test (as internal validation), quality factor, fischers test, root mean square deviation (RMSD), standard deviation, variance, Y-randomization test etc.; have been performed and all the tests validated this QSAR model with fraction of variance r2= 0.8138 and LOO-CV q2 = 0.7887.